The geochemistry and mineralogy of coal and coal-bearing strata from the Cannock Coalfield with special reference to chlorine.

The project was conducted on four coals seams, the Shallow and Yard (Lower Coal Measures) from Lea Hall Colliery at Rugeley, and the Park and-Eight Feet seams from Littleton Colliery, near Cannock. Ultimate, proximate analyses and moisture contents showed them to be of high volatile bituminous 'B' coal-rank, and typical of high Cl coals. The Cl investigation showed a relationship with organic matter where ash is a dilutant, reaching c. 1% (by weight) in the coals, almost an order higher than in the associated mudrocks. It is related to the internal surface area and is thus highest in the vitrinite dominated 'bright rocks' and lowest in the 'dull coals'. Two types of Cl were identified, originating from saline ground waters, the former representing present ground water solutions trapped in the larger pores and readily water-soluble, and the latter held in organic combination within smaller or closed pores produced by Hercynian rank imposition. Varying levels of this Cl can be released by ion exchange with carbonates in leaching experiments. The mudrock and coal ash mineralogy was conducted on low temperature ashed material which suffered the side-effect of gypsum formation during oxidation. The mudrock mineralogy is dominated by detrital minerals, quartz and clays predominating. Diagenetic minerals rarely account for 7% of the normative minerals except in localised pyrite and siderite nodules., Climate played an important role in the detrital mineralogy, the lower seam floor measures being dominated by a tropically leached suite of kaolinite and quartz. Continental movement led to increased aridity characterised by illite and chlorite which dominate the higher seams. The intraseam dirt bands are composed of very fine clays, rapidly deposited over wide areas by minor base-level changes or river (ii) bank bursts. The roof measures show least evidence of leaching and are often highest in diagenetic siderite. Ba, Sr, Rb (illite) and Zr (zircon) are predominantly detrital trace elements whilst oxyhydroxide material was-the transporting media. for the diagenetically located elements, Ni, Pb (pyrite), Co and Mn (siderite). Cu is primarily associated with organic matter. The detrital coal mineralogy reflects the fine mudrock material and is usually highest associated with the dirt bands. Diagenetic minerals dominate the ash, reaching 95% (by weight), the major component being late diagenetic cleat. A paragenetic sequence of mineralisation follows a widespread trend from sulphides, silicates to carbonates reflecting changing ground water composition. The cleat fractures represent microjointing produced with stress release during uplift. Its frequence decreases with bed thickness, and the brittle nature of vitrinite causes it to have the earliest formed and most abundant cleat. The strength of multimaceral lithotypes such as durain is much greater and therefore fracture least, later änd with a greater dilation

Awareness of lifestyle and colorectal cancer risk:findings from the BeWEL study

It is estimated that 47% of colorectal cancers (CRC) could be prevented by appropriate lifestyles. This study aimed to identify awareness of the causes of CRC in patients who had been diagnosed with a colorectal adenoma through the Scottish Bowel Screening Programme and subsequently enrolled in an intervention trial (using diet and physical activity education and behavioural change techniques) (BeWEL). At baseline and 12-month follow-up, participants answered an open-ended question on factors influencing CRC development. Of the 329 participants at baseline, 40 (12%) reported that they did not know any risk factors and 36 (11%) failed to identify specific factors related to diet and activity. From a potential knowledge score of 1 to 6, the mean score was 1.5 (SD 1.1, range 0 to 5) with no difference between intervention and control groups. At follow-up, the intervention group had a significantly greater knowledge score and better weight loss, diet, and physical activity measures than the control group. Awareness of relevant lifestyle factors for CRC remains low in people at increased risk of the disease. Opportunities within routine NHS screening to aid the capability (including knowledge of risk factors) of individuals to make behavioural changes to reduce CRC risk deserve exploration.Additional co-author: The BeWEL team. The BeWEL Team consists of Shaun Treweek, Fergus Daly, Jill Belch, Jackie Rodger, Alison Kirk, Anne Ludbrook, Petra Rauchhaus, Patricia Norwood, Joyce Thompson, and Jane Wardle

Integrating agroecology and participatory action research (PAR): Lessons from Central America

The last decade has seen an increasing advancement and interest in the integration of agroecology and participatory action research (PAR). This article aims to: (1) analyze the key characteristics and principles of two case studies that integrated PAR and agroecology in Central America; and (2) learn from the lessons offered by these case studies, as well as others from the literature, on how to better integrate PAR and agroecology. Key principles identified for effective PAR agroecological processes include a shared interest in research by partners, a belief in collective power/action, a commitment to participation, practicing humility and establishing trust and accountability. Important lessons to consider for future work include: (1) research processes that did not start as PAR, can evolve into it; (2) farmer/stakeholder participation in setting the research agenda, from the outset, results in higher engagement and enhanced outcomes; (3) having the right partners for the desired outcomes is key; (4) intentional and explicit reflection is an essential component of PAR processes; and (5) cross-generational collaborations are crucial to long-term benefits. Key challenges that confront PAR processes include the need for time and resources over longer periods; the complexity of multi-actor process facilitation; and institutional barriers within the academy and development organizations, which prevent shifting investment towards integrated PAR agroecological processes

Meeting the challenges of recruitment to multicentre, community-based, lifestyle-change trials : a case study of the BeWEL trial

Peer reviewedPublisher PD

Detailed protocol for the lifestyle intervention in the BeWEL randomised controlled trial of weight loss in adults who have had a colorectal adenoma

Introduction: The BeWEL study is aimed at assessing the impact of a personalised lifestyle programme on body weight in people at risk of developing colorectal adenomas. The study is a two-arm multicentre randomised controlled trial comparing the BeWEL lifestyle programme against usual care. Over 12 months, 316 people who have had a colorectal adenoma removed through the national screening programme will be randomised to provide 80% power to detect a weight loss (primary outcome) of 7% over 12 months. Methods: The 12-month intervention will be delivered by lifestyle counsellors via three face-to-face visits followed by nine monthly telephone support calls. Consultant endorsement for the study will be stressed. An individualised caloric prescription based on estimates for weight maintenance -600 kcal will be calculated. Motivational interviewing techniques will be used to identify personal motivations for weight change and ways to improve perceived self-efficacy. The programme will utilise personalised diet and physical activity data from baseline measures to set behavioural goals. A range of behavioural strategies will be employed to support lifestyle change including goal setting, identifying specific implementation intentions, self-monitoring and feedback. Emphasis will be placed on self-monitoring body weight, and weighing scales will be provided. Programme acceptability will be explored postintervention with indepth interviews. Compliance and impact will be assessed by baseline and follow-up measures of diet by self-report, activity by accelerometry and anthropometry. Ethics and dissemination: Ethical approval has been obtained from the Tayside Committee on Medical Research Ethics. Dissemination of results will focus on publications in peer-reviewed journals, presentations at national/international cancer meetings and NHS groups. In addition, the work will be communicated to the public through forums such at The Scottish Cancer Prevention Network (http://www.cancerpreventionscotland.co.uk/). The trial is registered with Current Controlled Trials (International Standard Randomised Controlled Trials No: ISRCTN53033856)

A New Young Galactic Supernova Remnant Containing a Compact Object: G15.9+0.2

We identify the radio-emitting shell-type supernova remnant G15.9+0.2 as a relatively young remnant containing an X-ray point source that may be its associated neutron star. The integrated spectrum of the remnant shell obtained from our 30 ks exploratory Chandra observation shows very strong lines that require elevated element abundances from ejecta, in particular of sulfur. A plane-shock model fit gives a temperature $kT = 0.9 (0.8, 1.0)$ keV, an ionization timescale $n_et = 6 (4, 9) \times 10^{10}$ cm$^{-3}$ s, and a sulfur abundance of 2.1 (1.7, 2.7) times solar (90% confidence limits). Two-component models with one solar and one enriched component are also plausible, but are not well constrained by the data. Various estimates give a remnant age of order $10^3$ yr, which would make G15.9+0.2 among the dozen or so youngest remnants in the Galaxy. The sparse point source spectrum is consistent with either a steep $\Gamma \sim$ 4 power law or a $kT \sim$ 0.4 keV blackbody. The spectrum is absorbed by a H column density $N_H \sim 4 \times 10^{22}$ cm$^{-2}$ similar to that required for the remnant shell. The implied 2--9.5 keV source luminosity is about $10^{33}$ ergs s$^{-1}$ for an assumed distance of 8.5 kpc consistent with the high absorption column. We suggest that the point source is either a rotation-powered pulsar or a compact central object (CCO)

Agroecología e Investigación-Acción Participativa (IAP): Principios y Lecciones de Centroamérica

The last decade has seen an increasing advancement and interest in the integration of agroecology and participatory action research (PAR). This article aims to: (1) analyze the key characteristics and principles of two case studies that integrated IAP and agroecology in Central America; and (2) learn from the lessons offered by these case studies, as well as others from the literature, on how to better integrate PAR and agroecology. Key principles identified for effective PAR agroecological processes include a shared interest in research by partners, a belief in collective power/action, a commitment to participation, practicing humility and establishing trust and accountability. Important lessons to consider for future work include: (1) research processes that did not start as PAR, can evolve into it; (2) farmer/stakeholder participation in setting the research agenda, from the outset, results in higher engagement and enhanced outcomes; (3) having the right partners for the desired outcomes is key; (4) intentional and explicit reflection is an essential component of IAP processes; and (5) cross-generational collaborations are crucial to long-term benefits. Key challenges that confront IAP processes include the need for time and resources over longer periods; the complexity of multi-actor process facilitation; and institutional barriers within the academy and development organizations, which prevent shifting investment towards integrated IAP agroecological processes.En la última década se ha visto un avance y un interés cada vez mayores sobre la integración de la agroecología y la investigación acción participativa (IAP). Este artículo tiene los siguientes objetivos: (1) analizar las características y principios clave de la IAP, usando dos estudios de casos que integraron IAP y agroecología en América Central; y (2) aprender de las lecciones ofrecidas por estos estudios de caso y otros de la literatura, sobre cómo integrar mejor IAP y agroecología. Los principios clave identificados para los procesos agroecológicos efectivos de IAP incluyen un interés compartido en la investigación por parte de los socios, una creencia en el poder / acción colectiva, un compromiso con la participación, la práctica de la humildad y el establecimiento de la confianza y la responsabilidad. Las lecciones importantes a considerar para el trabajo futuro incluyen: (1) procesos de investigación que no comenzaron con un enfoque de IAP, pueden evolucionar para incoporarlo; (2) la participación de los agricultores / partes interesadas en el establecimiento de la agenda de investigación, desde el comienzo, resulta en una mayor participación y mejores resultados; (3) tener los socios adecuados para los resultados deseados es clave; (4) la reflexión intencional y explícita es un componente esencial de los procesos de IAP; y (5) las colaboraciones intergeneracionales son cruciales para los beneficios a largo plazo. Los desafíos clave que enfrentan los procesos de IAP incluyen la necesidad de tiempo y recursos durante períodos más largos; la complejidad de la facilitación de procesos con múltiples actores; y las barreras institucionales dentro de la academia y las organizaciones de desarrollo, que aún no adoptan e inverierten adecuadamente en procesos agroecológicos integrales de IAP

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR

The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream sites. In this work, we have investigated the different determinants needed for optimal repression and their spatial requirements. We show that repression requires a complex involving four DNA-bound MelR molecules, and that the global CRP regulator plays little or no role

Ecological equivalence: a realistic assumption for niche theory as a testable alternative to neutral theory

Hubbell's 2001 neutral theory unifies biodiversity and biogeography by modelling steady-state distributions of species richness and abundances across spatio-temporal scales. Accurate predictions have issued from its core premise that all species have identical vital rates. Yet no ecologist believes that species are identical in reality. Here I explain this paradox in terms of the ecological equivalence that species must achieve at their coexistence equilibrium, defined by zero net fitness for all regardless of intrinsic differences between them. I show that the distinction of realised from intrinsic vital rates is crucial to evaluating community resilience. An analysis of competitive interactions reveals how zero-sum patterns of abundance emerge for species with contrasting life-history traits as for identical species. I develop a stochastic model to simulate community assembly from a random drift of invasions sustaining the dynamics of recruitment following deaths and extinctions. Species are allocated identical intrinsic vital rates for neutral dynamics, or random intrinsic vital rates and competitive abilities for niche dynamics either on a continuous scale or between dominant-fugitive extremes. Resulting communities have steady-state distributions of the same type for more or less extremely differentiated species as for identical species. All produce negatively skewed log-normal distributions of species abundance, zero-sum relationships of total abundance to area, and Arrhenius relationships of species to area. Intrinsically identical species nevertheless support fewer total individuals, because their densities impact as strongly on each other as on themselves. Truly neutral communities have measurably lower abundance/area and higher species/abundance ratios. Neutral scenarios can be parameterized as null hypotheses for testing competitive release, which is a sure signal of niche dynamics. Ignoring the true strength of interactions between and within species risks a substantial misrepresentation of community resilience to habitat los